Dopaminergic and cholinergic lesions in progressive supranuclear palsy
Identifieur interne : 000322 ( France/Analysis ); précédent : 000321; suivant : 000323Dopaminergic and cholinergic lesions in progressive supranuclear palsy
Auteurs : Merle Ruberg [France] ; France Javoy-Agid [France] ; Etienne Hirsch [France] ; Bernard Scatton [France] ; Rémy Lheureux [France] ; Jean-Jacques Hauw [France] ; Charles Duyckaerts [France] ; Françloise Gray [France] ; Ariel Morel-Maroger [France] ; André Rascol [France] ; Michel Serdaru [France] ; Agid [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 1985-11.
Abstract
In 9 patients with progressive supranuclear palsy and in 27 controls, dopamine and homovanillic acid concentrations, choline acetyltransferase (CAT) activity, and the number of [3H]spiperone and [3H]quinuclidinyl benzilate binding sites were measured post mortem in the striatum (caudate nucleus, putamen, and nucleus accumbens), substantia innominata, and frontal cortex. Dopamine and homovanillic acid concentrations were reduced in the caudate nucleus and putamen but not in the nucleus accumbens or frontal cortex, indicating that the nigrostriatal dopaminergic system is lesioned in patients with progressive supranuclear palsy (as in those with Parkinson's disease) but not the mesocortical and mesolimbic dopaminergic systems, which are lesioned in parkinsonian patients. CAT activity and [3H]spiperone binding decreased in parallel fashion in all the structures. In the striatum, this suggests that the cholinergic neurons, which are target cells of the nigrostriatal system, also degenerate in this disease. This might explain the decrease in the number of dopamine receptors as well as the inefficacy of levodopa or anticholinergic therapy in these patients. The decrease in CAT activity in the substantia innominata and the frontal cortex indicates that the innominatocortical cholinergic system is lesioned in patients with progressive supranuclear palsy and may play a role in the intellectual deterioration observed. This lesion is also found in demented patients with Alzheimer's and Parkinson's diseases.
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DOI: 10.1002/ana.410180503
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Dopamine and homovanillic acid concentrations were reduced in the caudate nucleus and putamen but not in the nucleus accumbens or frontal cortex, indicating that the nigrostriatal dopaminergic system is lesioned in patients with progressive supranuclear palsy (as in those with Parkinson's disease) but not the mesocortical and mesolimbic dopaminergic systems, which are lesioned in parkinsonian patients. CAT activity and [3H]spiperone binding decreased in parallel fashion in all the structures. In the striatum, this suggests that the cholinergic neurons, which are target cells of the nigrostriatal system, also degenerate in this disease. This might explain the decrease in the number of dopamine receptors as well as the inefficacy of levodopa or anticholinergic therapy in these patients. The decrease in CAT activity in the substantia innominata and the frontal cortex indicates that the innominatocortical cholinergic system is lesioned in patients with progressive supranuclear palsy and may play a role in the intellectual deterioration observed. This lesion is also found in demented patients with Alzheimer's and Parkinson's diseases.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Île-de-France</li></region><settlement><li>Bagneux</li><li>Paris</li><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></region><name sortKey="Agid" sort="Agid" uniqKey="Agid" last="Agid">Agid</name><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><name sortKey="Gray, Francloise" sort="Gray, Francloise" uniqKey="Gray F" first="Françloise" last="Gray">Françloise Gray</name><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name><name sortKey="Hirsch, Etienne" sort="Hirsch, Etienne" uniqKey="Hirsch E" first="Etienne" last="Hirsch">Etienne Hirsch</name><name sortKey="Javoy Gid, France" sort="Javoy Gid, France" uniqKey="Javoy Gid F" first="France" last="Javoy-Agid">France Javoy-Agid</name><name sortKey="Lheureux, Remy" sort="Lheureux, Remy" uniqKey="Lheureux R" first="Rémy" last="Lheureux">Rémy Lheureux</name><name sortKey="Morel Aroger, Ariel" sort="Morel Aroger, Ariel" uniqKey="Morel Aroger A" first="Ariel" last="Morel-Maroger">Ariel Morel-Maroger</name><name sortKey="Rascol, Andre" sort="Rascol, Andre" uniqKey="Rascol A" first="André" last="Rascol">André Rascol</name><name sortKey="Scatton, Bernard" sort="Scatton, Bernard" uniqKey="Scatton B" first="Bernard" last="Scatton">Bernard Scatton</name><name sortKey="Serdaru, Michel" sort="Serdaru, Michel" uniqKey="Serdaru M" first="Michel" last="Serdaru">Michel Serdaru</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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